COX-2 Inhibitor Drug Review

Supplemental results to the large COX-2 inhibitor review in JAMA: "Adverse Effects of Cyclooxygenase-2 Inhibitors on Renal and Arrhythmia Events: Meta-Analysis of Randomized Trials"

Official supplemental website authorized by the executive editors of Journal of the American Medical Association

Full text of study available via JAMA

Geo-distribution of visitors to COX2DrugReview.Org


Supplemental forest plot results for rofecoxib (VIOXX) . Please view the desired forest plots below. Bars represent the upper and lower 95% confidence bounds, X-axis label is "Relative risk".

[For information on methods and primary results, please see the original article]

[Additional tests for publication bias for each COX-2 inhibitor available here]

Composite Renal

Peripheral Edema


Renal Dysfunction


*Note: Sensitivity analysis via Mantel-Haenszel pooling and Fisher’s Exact Test, methods more exact and optimal for sparse-events data, both further affirmed the increased risk of arrhythmia with rofecoxib (Mantel-Haenszel RR=6.52, 95% CI: 1.48-28.8; Fisher’s Exact P value=0.004).

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