Rofecoxib

Supplemental forest plot results for rofecoxib (VIOXX) . Please view the desired forest plots below. Bars represent the upper and lower 95% confidence bounds, X-axis label is "Relative risk".

[For information on methods and primary results, please see the original article]

[Additional tests for publication bias for each COX-2 inhibitor available here]

Composite Renal

Peripheral Edema

Hypertension

Renal Dysfunction







Arrhythmia*

*Note: Sensitivity analysis via Mantel-Haenszel pooling and Fisher’s Exact Test, methods more exact and optimal for sparse-events data, both further affirmed the increased risk of arrhythmia with rofecoxib (Mantel-Haenszel RR=6.52, 95% CI: 1.48-28.8; Fisher’s Exact P value=0.004).