COX-2 Inhibitor Drug Review

Supplemental results to the large COX-2 inhibitor review in JAMA: "Adverse Effects of Cyclooxygenase-2 Inhibitors on Renal and Arrhythmia Events: Meta-Analysis of Randomized Trials"

Official supplemental website authorized by the executive editors of Journal of the American Medical Association

Full text of study available via JAMA

Geo-distribution of visitors to COX2DrugReview.Org

Valdecoxib and Parecoxib

Supplemental results for Valdecoxib and Parecoxib (BEXTRA® and DYNASTAT®) . Please view the desired forest plots below. Bars represent the upper and lower 95% confidence bounds, X-axis label is "Relative risk".

[For information on methods and primary results, please see the original article]

[Additional tests for publication bias for each COX-2 inhibitor available here]

Composite Renal (both drugs)

Composite Renal (Valdecoxib-only trials)

Peripheral Edema (both drugs)

Hypertension (both drugs)

Renal Dysfunction (both drugs)

Arrhythmia (both drugs)

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